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Patna (BiharTimes):Professor Dr Hari Shanker Sharma, a native of Bihar, born in Dalmianagar, Rohtas, and educated in Bihar (a gold medalist from Bihar University, Muzaffarpur) and D. Phil (Neuroscience) from Banaras Hindu University, Varanasi currently working in Uppsala University Hospital, Sweden as Director of research, Central nervous system (CNS) Injury & Repair since 1988 was selected for the coveted US Neurosurgeon Dr Antony Marmarou Award of 2011. Dr Sharma will be given this award in a glittering ceremony on October 24, 2011 in Tokyo. |
 Dr Anthony Marmarou devoted his lifetime to understand development of brain edema, e.g., swelling of the brain caused by trauma, ischemia or any severe insult to the brain leading to accumulation of water in the brain and/or spinal cord. Dr Marmarou focused his attention to find out a suitable therapy to treat patients of brain injuries. The most important causes of death include increase in intracranial pressure, i.e., pressure of cerebrospinal fluid (CSF) that is circulating inside and outside of the brain to act as cushion against injury. Dr Marmarou focused this increase in CSF pressure in animal models of closed head injury (CHI) that means when skull is not fractured. The CHI induces much more brain swelling due to concussion rather than open brain injury (OBI) leading to fractures where the brain is allowed to swell or bulge so that other parts of the brain are not affected or compressed. The mechanism of such brain swelling is still unclear.
Dr Sharma and his team from Uppsala University meticulously showed that brain swelling occurs when the blood-brain barrier (BBB), a barrier within the blood vessel lining restricts the entry of water and proteins into the brain under normal conditions, is broken down. Dr Sharma's research using light and electron microscopy further show that if this BBB is tightened by use of drugs, antibodies of growth factors, swelling of the brain could not occur evens after sever trauma. This research of Dr Sharma and his team is finally recognized by the Brain Edema Society comprises largely neurosurgeons. On this fundamental discovery and contribution by Dr Sharma as a team leader in brain edema field the Brain Edema Society wanted to honor him. As a result and on the assessment of Dr Sharma's active involvement to this society since last 33 years, the society has chosen to honor him with Dr Anthony Marmarou Award in their 46th years of conference in Tokyo on “Brain Edema And Tissue Injury”. It is hoped that with this award Dr Sharma and his International team will be encouraged to continue this type of Research in order to find some cure for brain edema, a leading cause of death in patients with brain anomalies Worldwide.
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