(Bihar Times) When I was young, every school had to cut up animals to learn biology. Years later, the education system realized that cutting animals harmed the child. So schools were ordered to stop it.
Zoology dissection has been stopped by order of the UGC. Even medical colleges have realized that cutting animals by undergraduate students makes no sense and are planning to stop it. Pharmacy and dental colleges have already stopped it. In a few years dissection will become a horrible memory.
Now come to the so called research for a great medical breakthrough. India just has one patent. But millions of animals have been killed by so called researchers. In fact, after all the killing and their monthly salary, few even write up the experiments on animals. The premier Medical Journal Lancet says that only 2% of research in India is written up and submitted for review.
Indian researchers are not the only fakers in the field.
Every few days I see some new headline in the paper about a new cure for cancer. When I read the article it says that some breakthrough has been made when testing animals. Months later the “breakthrough” has failed in clinical trials on humans and is abandoned. The researchers get their grants and after a few days another study will start. Lakhs of animals are dead but 90% of the researchers achieve nothing.
And they cannot. Animal testing leads nowhere. Can a test on a human be applicable to a rat? No. So why should medicines that work on rats be applicable to humans?
My scepticism is borne out by an amazing 2010 University of Edinburgh study which has found that published animal trials tend to overestimate the likelihood that a medical treatment will work by about 30% or more.
Researchers suggest that the main cause for this is because negative results during animal trials often go unpublished.
Based on analysis of 525 “breakthrough” studies on strokes including 1,359 experiments and 16 different treatments, researchers found that only about a third of these results were even reproducible in human trials. A major overstatement of efficiency has become par for the course.
Why are researchers telling lies?
Researchers suffer from “Publication Bias”. They know that negative or neutral results are not interesting enough to be published or talked about. However when positive results are obtained from an animal trial they will get published - in journals, review articles, textbooks, courses - leading to fame for the researcher amongst his peers and making his viewpoint the “truth”. But if data is not published because it is negative or differs substantially from published work, then the researcher has to find something else to do.
The Study reported that only 10 publications (2%) printed research that was negative. Only 6 had reports that did not make some significant new claim. 214 experiments apart from the 1359 which found negative findings in the same area were not printed at all.
Non-publication of data raises ethical concerns, first because the animals used have not contributed to the sum of human knowledge, and second because participants in clinical trials may be put at unnecessary risk if efficacy in animals has been overstated. But because the truth is hidden, animal testing continues in the life sciences and medical research. If researchers knew the truth – that a great deal of research fails because of the animal models used – then they would look for alternatives. We may even find the actual cures for diseases like cancer that we are pretending to treat now.
The impact of publication bias in basic research has not previously been quantified. The Edinburgh research has for the first time shown that publication bias is prevalent in reports of laboratory-based research in animal models to the extent that as many as one in seven experiments remain unpublished and reviews of the results of interventions in animals overstate their efficacy by around one third.
Misleading or one sided research data can go on compounding the problem, leading new researchers down the garden path as they attempt to build on already published data. Let me explain it simply:
Ten experiments take place that say colouring a rat’s ears can cure cancer. Nine say that it has no effect on the disease at all. None of these nine experiments are published. But the tenth which says that colouring the ears of a rat MAY have some effect on cancer will be published as a “breakthrough”. New researchers only see this one published article. So they get put in years trying to find out which other ear colours could cure cancer. If they had read the unpublished works they would have abandoned this line of research altogether instead of further unnecessary animal experiments testing poorly founded theories.
Some safeguards are built into the system of information dissemination by making a published article open to review. But it is a hit and miss method with “experts” using review articles to emphasise their own particular perspective and again without digging into the data that has NOT been published.
This is what the Edinburgh researchers say “ If experiments have been conducted but are not available to reviewers, as they are not the same as results from experiments that were published, then reviews, and the resulting expert opinion and public understanding, will be biased. This is the “file drawer problem”: at its most extreme, the 95% of studies that were neutral and reported no significant effects remain in the files of the investigators, while the 5% of experiments that were falsely positive are published, and reviewers conclude—falsely—that the literature represents biological truth.”
If publication bias did not exist, at least one-third of animal-based experiments would have shown different results. In fact the Study says “We think that the present study is more likely to underestimate than to overestimate the effect of publication bias.”
What are the reasons that researchers look for “positive hyped results, no matter what the truth is:
1. First, there is likely to be more enthusiasm amongst scientists, journal editors, and the funders of research for positive rather than for neutral studies.
2. The majority of animal based studies use only a few animals. Neutral studies therefore seldom have the statistical power confidently to exclude an effect that would be considered of biological significance, so they are less likely to be published than are similarly underpowered “positive” studies.
How many animals were killed in those 214 experiments that were never reported? 3,600.
What is the solution to this? A central register of experiments involving animals should be made so that anyone entering the field can access the number of experiments grouped along a broad subject. In England www.clinicaltrials.gov logs all clinical trials before they begin.
The value of animal experiments for predicting the effectiveness of treatment strategies in clinical trials has remained controversial. Animal experiments may contribute to our understanding of mechanisms of disease, but their value in predicting the effectiveness of treatment strategies is extremely limited. Less than 10% even translate into clinical trials on humans. I could give you a list of thousands of medicines that worked in animals and failed in humans.
The purpose of the Edinburgh study was to convince scientists and journals to publish rigorously conducted negative studies as well. If we publish all the times that experiments on animals have failed, we might get researchers to go to the track of serious science instead of wasting time.
To join the animal welfare movement contact firstname.lastname@example.org
Animal Studies Paint Misleading Picture
Are you alone?
What do you eat when you eat fish
How ANIMALS manage their time—A STUDY
Next time you look into your beloved’s soul, look for the parasites at the gateway...
Medicinal Use of Cow Urine
Influence of Animals on human beings
Cruel Ways of Eating Animals & Birds by Humans II
Cruel Ways of Eating Animals & Birds by Humans I
Are you a Good Samaritan?
How to Check Adulteration in Milk
Stable Environment for healthy fish needed
Fish Lovers- Beware
Role of Bacteria in shaping behavior of genes
A Suitable Cow
Some Tips On Nursing Puppies
Ban Battery cage for chicken
Varieties of Chicken we eat
Slaughter houses and increased crime rates
Breeds of dog in India
Cruelty to animals on the occasion of festivals
Real foods spoil very quickly, fast foods not
The Myth of Swine & Avian Flu in India
Fish eating causes health hazard
Animal sacrifice in Pauri Garhwal area of Uttarakhand
Difference between Veg and Non-veg
Virgin Mary among Lizards
Nature-the most inspiring model for our Ecosystems
Role of denial in eating of Meat
The Technology of Synthetic Milk
Honeybee-the insect for human food chain
Why do dogs bark
Characteristics of varieties of caterpillars
Emotional Complexity of Animals
Meat eating causes diseases
Rat in Hindu mythology
Which animal you are
Man’s alter ego-an Animal
Career in management of welfare of Animals
Profession of Pet grooming
What you Eat When you Eat Processed Meat
How to train a dog to make it useful
The Purpose of Minor Beings in Our Ecosystem
Cruelty to Bears in Pakistan
How Onion Drives Away Viruses
How to save an animal from burn injury
Production of Honey is cruelty to Bee
Meat eating causes Global warming
Hazards of fish factories
Growth of a bird till it flies
Creatures of the world live and help live
Killing a snake brings bad luck
Effects of the startle Reflex on Animals
Awaken Your Soul by Loving Animals
Feeling of grief in Animals
Altruism in Animals
Music Soothes Animals
How Animals recognize their Kins
Animals teach their offspring like human moms
Cruelty to Animals in Slaughter houses
What is the secret to a perfect life and happiness?
How is Ghee being adulterated ?
Difference between a man & an animal
Homosexuality Is Not Against Nature In Animal Kingdom
Programmes for improving Animal Welfare
Promiscuity in mating behaviour of Birds
Uses for slaughtered Animals accelerate killing of Animals
Slingshots & Catapults Destroy Wild Life
Human Intelligibility of Animals
Animal grooming of offspring is worth emulating
Illegal Trade of Killing Cattle
Eating Cattle Meat Causes E Coli Infection
Some tips on making Puppies’ life comfortable
Some tips on keeping kittens clean
Snake skin trade dangerous for eco system
Dog shows are not for dog lovers but for moneymakers and charlatans
Political agenda for Animal welfare needed
How foolish it is to kill Sea creatures for Ornaments
Infectious diseases from Animals to Humans
How pitiable is Rabbit farming?
Remedies for Animal ailments
Infected Pig Meat Risks Your Life
Animals spread dangerous Ebola virus to humans
Animals Have More Sense
Municipal Policy on hazards of pet shops
Mutualism makes Species of the nature flourish
Adoption Fair for Puppies
How Animals behave in packs
Why People prefer dogs and cats to human beings
Positive effects of spaying and neutering on pets
Mammals & Birds cry like human beings
Biomemetics Provides solution to human problems
Chinese food products- the greatest killer
Pets make better partners than humans
How harmful is the Packaged Meat
Stop Slaughter of Cows for Bone Trade
How cruel it is to dump pet animals ? view comments...
Don’t hurt animals on festive occasions
Let the earth beings survive
Glues are made of animal remains
Meat increases risk of cancer
Birds provide springboard to song composers
Is it not an act of Cannibalism?
How many animals do you have to eat before you become man ?
To eat or not to eat Meat
Insulin from Animals
Is It Healthy Decision to Promote Rat Eating in Bihar
Use of Animal bones in Porcelain
Infection of Tick disease in Dogs and its cure
Vegetarian diet is the best diet for human beings
Non-Veg Diet causes Dementia
Excuses for being non-vegetarians
Body odour of Non-vegetarians
MEAT threatens Planet’s Survival
Am I smarter than you ? Yes, if you are a meat eater.
Need to orient educational system to deal with animals
How to Avoid Cruelty to Gold Fish?
How To Make Everyday An Animal day
Are Eggs Vegetarian?
Are You One of these People ?
Use of Animal Fats in Cosmetics Industries
Killing of endangered Species for Perfume Industries
Missionary Campaign to Control Cruelty to Animals- needed
Drink Milk, Get Sick
Parents Create Monsters
The Business of Murder:Factory Farming and the Meat Industry in India
Effect of landscaping of birds on environment
Dangers of killing deep Sea-Sharks for Cosmetic Products
Use of dog in diagnosis of diseases
Sacred Nature of Neelkanth
Cruelty to Polo Ponies comments...
Self-Regulation of Population by Animals
Dangers of Animal meat eating
Arsenic poison in chicken feed
Cruelty to Animals by Govt. Vets
Worship of God with Blood and Suffering of Animals and Birds
Consequences of Chloramphenicol in Shrimp Industry
Hazards of Trade in Peacocks’ Feather
Supreme Court Ban on cruelty to Animals
Are you a Bad Pet Owner?
The Goat That Laughed and Wept
Animal Owners’ personality traits resemble their Pets’
Human Propensities of Goat
sacrifice at the altar of religion
as foster parent
feed from rendering plant
Intelligence of Birds
Human Propensities of Cow